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What is Viagra (sildenafil)?

Viagra (sildenafil) is used to treat erectile dysfunction. Erectile dysfunction is the inability to get or keep an erection for satisfactory sexual activity in men, also known as impotence. Sildenafil belongs to a class of medications called phosphodiesterase type5 (PDE5) inhibitors. Viagra works by relaxing muscles found in the walls of blood vessels and increasing blood flow to the penis during sexual stimulation to get and keep an erection. Keep in mind that Viagra does not cure erectile dysfunction or increase sexual desire.

under the brand Revatio is also used to treat pulmonary atrial hypertension (PAH). If you are taking Revatio do not take Viagra unless directed by your physician.

Buy Viagra Online : Know the Dosage

The recommended dose is 50mg about 1 hour before sexual activity, but it can be taken from 30 minutes to 4 hours before intercourse. The maximum daily dosage is once per day, with or without food. The dosage can be increased to 100mg or decreased to 25mg based on toleration and effectiveness. Viagra 100mg are available in KamaHealth.

Side Effects

MedicationOnsetDuration
Sildenafil (Viagra)30-60 minutes4-5 hours

The most common side effects consist of the following:

  • Headache, nausea, and dizziness
  • Stuffy nose, nosebleed
  • Temporary redness of neck and face
  • Backache, indigestion

If you are a heart patient, sexual activity could put extra strain on your heart. If you experience the following serious side effects while having sex, stop and get medical help right away. The side effects include:

  • Severe dizziness
  • Nausea
  • Chest/jaw/left arm pain
  • Fainting

Some patients may experience serious side effects; if you experience these, get medical help right away. Serious side effects include:

  • Temporary memory loss
  • Seizures
  • Serious allergic reaction, including rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, and trouble breathing.

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100mg. Avoid high-fat meals that contain large amounts of fat, and try to take in- 30 minutes before you start using this medicine.This ensures maximum blood flow to the penis and prevents erectile dysfunction. It's important to take sildenafil at the same time for optimal results.

Viagra:

Revatio is a treatment for pulmonary atrial hypertension (PAH).

Pulmonary atrial hypertension is a class of drugs that affect the heart. PAH is a type of heart attack that occurs during or right before sexual activity. Viagra can help improve your heart function and may help you learn to take smaller amounts of your daily medication.

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A study in South Wales shows that the drug sildenafil can be used safely and effectively for patients who are not fully satisfied with the results of their erectile dysfunction (ED) or premature ejaculation (PE) medications.

In a study of over a million men over the age of 40, researchers from the University of Cardiff have found that, in general, sildenafil is the most effective treatment for erectile dysfunction (ED) and is also used to treat PE. The men who took sildenafil were about 5 times more likely to have an erection (ED) than those who took placebo. The researchers also found that men who took sildenafil had a higher rate of ejaculation, as well as reduced time to ejaculation.

“Sildenafil has been shown to be highly effective in treating the symptoms of erectile dysfunction and PE,” said Professor Tom Lomelow, Director of the Sexual Medicine Research Centre in Swansea, and Chief Executive Officer for the University of Swansea.

“This shows that men who take sildenafil are less likely to suffer from PE and that the effects of sildenafil are far more significant than those of other treatments for ED.”

Sildenafil is a PDE5 inhibitor and the active ingredient is Viagra. The drug was approved by the European Medicines Agency in 1998 for treatment of erectile dysfunction (ED) and is available as a generic medication.

The study found that men who took sildenafil for a long time (greater than five years) had a greater chance of getting an erection (ED) than those who took placebo. This was due to an increased time to ejaculation which was about half that of the men who took sildenafil, and was found to be the longest.

Men taking sildenafil had a faster onset of action and a lower incidence of side effects compared with men who took placebo. This was also the same for men who had never taken the drug and those who had taken it in the last 3 months of the year.

“This is the first study to show that sildenafil can be safely used as a treatment for erectile dysfunction.”

Professor Lomelow said that while the study found that men who were not fully satisfied with their erections (ED) or ejaculating (PE) drugs were about 5 times more likely to suffer from PE than those who took placebo, the results of the study did not show that treatment with sildenafil was superior to that of placebo for this group of patients.

“The results do not support the use of sildenafil for treatment of premature ejaculation and are not consistent with the results of the research which found that the drug helped to delay ejaculation in a placebo-controlled trial.”

“In addition, the study did not show that the drug was better than placebo in controlling for other known risk factors such as age, smoking status, drinking status, obesity and blood pressure.”

The study also showed that sildenafil did not have any side effects in the men who took the drug, with the exception of nausea, headache and flushing.

Professor Lomelow said that the data was interesting and reassuring and that it was important to study men who were taking sildenafil to see if the drug was the same for them as for the men who were not fully satisfied with their erections.

“The results of the study do not support the use of sildenafil for treatment of premature ejaculation and are not consistent with the results of the research which found that the drug helped to delay ejaculation in a placebo-controlled trial.”

“Sildenafil is the only PDE5 inhibitor that has been shown to be highly effective in treating the symptoms of erectile dysfunction and PE.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
EU Anticancer Office for Healthcare Research and Development (6th http://www.euro.eu/en/EU/adult/europe)
  1. Note:The European your GP prescribes may have changed the prescription dosage from nitrates to nitric oxide donors.
  2. If you have been prescribed Cialis without an EU prescription, always consult your GP or pharmacist for details.
  3. For a full list of changes to take to your local pharmacy, see the “ http://www.euro.eu/va/getc/” section.
Detailed information on potential drug interactions

Possible Drug-Food Interactions:

Nitrates and other alpha-blockers can amplify the effects of Cialis, leading to a drop in blood pressure with potentially fatal outcomes. Tadalafil is an alpha-blocker used to treat erectile dysfunction (ED) by improving blood flow. Alpha-blockers can:

  • Attracting patients with benign prostatic hyperplasia (BPH) to Cialis.

Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Viagra use include:

  • Headache
  • Heartburn
  • Congestion
  • Nasal bleeding (bloody nose)
  • Nausea
  • Diarrhea
  • Muscle aches or pains
  • Flushing
  • Facial pain or tenderness
  • Vision changes
  • Light sensitivity

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

As with all prescription medications, inform your doctor of any medical conditions you used to get treatment for such as:
  • Under the age of 18
  • Placid or frontal cerebrovascular disease
  • Protein C deficiency
  • Protein A deficiency
  • Stable salt levels in your blood

If you have any dietary changes, vaginal bleeding problems, or current conditions that could make them worse to know that you are taking Viagra.

Tell your doctor if you are pregnant, may become pregnant, or are breastfeeding. You should not keep track of these changes.If you become pregnant, you should contact your doctor immediately. If a erection lasts more than 4 hours, contact your doctor. If you experience an erection that lasts more than 6 hours, consult your doctor immediately.wort

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How it works

Viagra contains sildenafil citrate, which is a PDE5 inhibitor. This medication works by relaxing the blood vessels in the penis, allowing for increased blood flow. This allows the man to get an erection when sexually aroused.

Viagra treats erectile dysfunction by increasing blood flow to the penis. This helps men get and keep an erection. Viagra is not recommended for women or children under 18 years of age. Viagra should not be taken by men under 18 years of age unless directed by a doctor. Viagra must be taken by men who are sexually active or have problems getting or maintaining an erection.